Lap-Chee Tsui
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Lap-Chee Tsui is a geneticist who discovered the mutated gene that causes cystic fibrosis, a deadly disease. A geneticist is a scientist that studies DNA in humans and animals.
December 26, 1950
Place of Birth
Shanghai, China
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Point A is Shanghai, China.
Known for
Lap-Chee Tsui is known for discovering the mutated gene that causes cystic fibrosis. He and his research team found the gene in 1989.
Science Explained
Cystic fibrosis is an inherited disease that is only inherited if both parents have the gene. If both parents have the cystic fibrosis gene, then they can expect that one out of every four of their children will have the disease. The gene that causes cystic fibrosis is called cystic fibrosis transmembrane conductance regulator, or CFTR, which lies in the middle of chromosome 7 and encodes a protein also called CFTR.
Cystic fibrosis causes sweat to have an abnormally high salt content. Because of this, a person can be tested for cystic fibrosis by analyzing the salt content in their sweat. Mutations related to cystic fibrosis can be detected in screening tests. This test can tell if a person is a carrier of the gene, but may not necessarily suffer the symptoms of cystic fibrosis. For example, a person can be a carrier of cystic fibrosis but not have the thick, sticky mucus in their lungs and digestive system.
Cystic fibrosis causes a buildup of thick and sticky mucus in the respiratory and digestive tracts. If the respiratory tract is obstructed, the person may have lung infections, may cough and wheeze persistently, and may have shortness of breath. In addition, the mucus might obstruct the pancreas, thus hindering the body's ability to break down food and absorb nutrients. If the pancreatic ducts are obstructed, the person may grow slowly and fail to gain weight.

Lap-Chee Tsui worked as a postdoctoral researcher at the Oak Ridge National Library in Oak Ridge, Tennessee. He also worked at the Hospital for Sick Children in Toronto Canada and was the Vice Chancellor of the University of Hong Kong.
Did you know?
Lap-Chee Tsui is shy and positive, and likes to laugh. His favorite music is the end of act one of Puccini’s opera, Turandot. He likes traveling, food, basketball, and drawing. He has a B.s and an M.Phil. in biology from the Chinese University of Hong Kong, and a PhD in Biological Science from the University of Pittsburgh. A famous quote from Lap-Chee is, “Knowing science can enrich your life. Basically, science is a foundation for genuine common sense.”
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Encyclopedia. Arizona State University, 2013. Web. 5 September 2013.
Winikates, Kristina. “Cystic Fibrosis.” Embryo Project Encyclopedia.

Arizona State University, 2013. Web. 5 September 2013.